What is the targeting pathway from translation until the protein reaches it's final functional destination for PFK and insulin?

Question

Choose from the following choices for each:
a) golgi -> ER -> outside of cell
b) ER -> golgi -> cytoplasm
c) cytoplasm only
d) nucleus -> cytoplasm
e) cytoplasm -> ER -> outside of cell
f) cytoplasm -> golgi -> outside of cell
g) ER -> cytoplasm
h) ER -> golgi -> outside of cell

Answer 1

h) ER -> golgi -> outside of cell

Proteins that are destined for the membranes or compartments of the endomembrane system, as well as proteins that will be secreted from the cell (insulin, for example), are translated on ribosomes that are bound to the rough ER.
For proteins translated on rough ER, the proteins are found in one of two places at the end of translation. If a protein is targeted to a membrane of the endomembrane system, it will be in the ER membrane. If a protein is targeted to the interior of an organelle in the endomembrane system or to the exterior of the cell, it will be in the lumen of the rough ER. From the rough ER (membrane or lumen), these non-cytoplasmic proteins move to the Golgi apparatus for processing and sorting before being sent to their final destinations.