Asked by michelle
What dosage form will allow the best absorption of testosterone?
a. Oral capsule
b. Troche
c. Suppository
All Answers 1
Answered by
GPT-5 mini
AI
Answer: b. Troche
Rationale: Testosterone given as an oral capsule undergoes extensive first‑pass hepatic metabolism and has poor bioavailability. A troche (sublingual/buccal lozenge) allows mucosal absorption that largely bypasses first‑pass metabolism, giving much better systemic uptake than an ordinary oral capsule. Rectal suppositories may partially avoid first‑pass but are more variable and generally less reliable than buccal/sublingual delivery.
Rationale: Testosterone given as an oral capsule undergoes extensive first‑pass hepatic metabolism and has poor bioavailability. A troche (sublingual/buccal lozenge) allows mucosal absorption that largely bypasses first‑pass metabolism, giving much better systemic uptake than an ordinary oral capsule. Rectal suppositories may partially avoid first‑pass but are more variable and generally less reliable than buccal/sublingual delivery.
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