Question

When a physician writes for Biest 5 mg, what amount of each estrogen is needed?
a. E3 = 2 mg, E2 = 0.25 mg, and E1 = 0.25 mg
b. E3 = 4 mg, E2 = 0.5 mg, and E1 = 0.5 mg
c. E3 = 4mg, E2 = 1 mg, and E1 = 0 mg

Answer 1

c. E3 = 4 mg, E2 = 1 mg, E1 = 0 mg

Biest is commonly prepared as an 80:20 mixture of estriol:estradiol, so a 5 mg total dose is 4 mg estriol + 1 mg estradiol (estrone typically not included).