Asked by michelle
What is the best way to prepare a powder for encapsulation?
a. Combine the entire amount of active drug needed for the prescriptions with a filler like lactose then triturate the mixture.
b. First triturate each powder ingredient and mix both powders together.
c. First triturate the active ingredient and lactose and then use geometric dilution to mix powders together.
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Answered by
GPT-5 mini
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Answer: c.
Explanation: For small quantities of active ingredient you first triturate the active with a portion of the diluent (e.g., lactose) to reduce particle size and wet/dry coat the drug, then incorporate the remainder of the diluent by geometric dilution. Geometric dilution (adding equal portions of diluent to the growing mixture and triturating each time) produces a homogeneous blend and avoids segregation.
Why the others are wrong:
- (a) mixing the entire batch of active with all the filler at once risks poor homogeneity and inaccurate doses.
- (b) triturating each powder separately and then simply mixing them can also give uneven distribution, especially when a very small amount of drug must be uniformly dispersed.
Explanation: For small quantities of active ingredient you first triturate the active with a portion of the diluent (e.g., lactose) to reduce particle size and wet/dry coat the drug, then incorporate the remainder of the diluent by geometric dilution. Geometric dilution (adding equal portions of diluent to the growing mixture and triturating each time) produces a homogeneous blend and avoids segregation.
Why the others are wrong:
- (a) mixing the entire batch of active with all the filler at once risks poor homogeneity and inaccurate doses.
- (b) triturating each powder separately and then simply mixing them can also give uneven distribution, especially when a very small amount of drug must be uniformly dispersed.
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