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What describes the mechanism of action of convenia
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Convenia (cefovecin) is a third‑generation cephalosporin antibiotic. Its mechanism of action:
- Bactericidal; it inhibits bacterial cell‑wall synthesis.
- Specifically, the beta‑lactam ring binds penicillin‑binding proteins (PBPs) and blocks the transpeptidation (cross‑linking) step of peptidoglycan synthesis.
- Loss of cell‑wall integrity leads to osmotic instability and bacterial lysis.
- It is time‑dependent killing and has prolonged activity in dogs and cats because of high protein binding and slow release from the injection site.
Notes: activity is against many susceptible Gram‑positive cocci and some Gram‑negative organisms; resistance mechanisms include beta‑lactamase production, altered PBPs, or reduced permeability.
- Bactericidal; it inhibits bacterial cell‑wall synthesis.
- Specifically, the beta‑lactam ring binds penicillin‑binding proteins (PBPs) and blocks the transpeptidation (cross‑linking) step of peptidoglycan synthesis.
- Loss of cell‑wall integrity leads to osmotic instability and bacterial lysis.
- It is time‑dependent killing and has prolonged activity in dogs and cats because of high protein binding and slow release from the injection site.
Notes: activity is against many susceptible Gram‑positive cocci and some Gram‑negative organisms; resistance mechanisms include beta‑lactamase production, altered PBPs, or reduced permeability.
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