Question

1) Which of the following testosterone replacement formulations is known for its rapid absorption and ability to maintain testosterone levels without affecting fertility?

Oral testosterone
Buccal testosterone
Nasal testosterone
Injectable testosterone
2) Which formulation of TRT involves a minor surgical procedure and provides consistent testosterone release for 3-6 months?

Transdermal patches
Injectable testosterone
Subdermal implants
Buccal testosterone
3) Which of the following is a key counseling point for patients using testosterone gels?

Apply the gel to the scrotum for best absorption
Avoid contact with others until the gel has dried
Rotate injection sites to avoid irritation
Buccal administration is recommended with meals
4) Which of the following is a well-documented benefit of TRT in older men with low testosterone levels?

Increased bone mineral density and bone strength
Improvement in cognitive function
Significant improvement in mood and depressive symptoms
Decreased risk of prostate cancer
5) Which of the following is a recognized risk of testosterone replacement therapy?

A decrease in lean body mass
Erythrocytosis
Decreased sexual function
Reduced grip strength
6) Which choice below is an opportunity for interprofessional team communication regarding patients utilizing testosterone?

The patient states they will visit the dentist three hours after applying testosterone gel formulation for a routine dental cleaning appointment.
The patient brings a prescription refill request and asks for some names of eardrops, telling the pharmacy technician an earache developed the day after the testosterone injection.
The patient receiving injected testosterone formulation asks for the shelf location of the decongestants because he developed a cold.
The patient states the testosterone laboratory appointment occurred last week, but the patient no longer has insurance and needs a low-cost option, or they will stop using it.
7) What is a common adverse effect associated with the use of testosterone gels?

Gum irritation
Skin reactions
Mood fluctuations and injection site pain
Increased sperm production
8) Which of the following is a key counseling point for patients using injectable testosterone?

Rotate injection sites to avoid irritation
Apply testosterone gel immediately after a shower
Store injections in the freezer for better efficacy
Take with food to improve absorption
9) What is the recommended storage method for testosterone gel formulations?

Refrigerate to prevent degradation
Store at room temperature, away from children
Keep it in the freezer to maintain potency
Store in a humid environment for better absorption
10) Which TRT formulation has the potential risk of accidental transference to women or children?

Injectable testosterone
Buccal testosterone
Nasal testosterone
Testosterone gel
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Answer 1

1) Nasal testosterone — rapid absorption and may preserve fertility better than many other TRT options.
2) Subdermal implants — minor office procedure; pellets release testosterone for ~3–6 months.
3) Avoid contact with others until the gel has dried — prevents accidental transference.
4) Increased bone mineral density and bone strength — a well-documented benefit in older men with low T.
5) Erythrocytosis — increased hematocrit/hemoglobin is a recognized risk of TRT.
6) The patient states the testosterone laboratory appointment occurred last week, but the patient no longer has insurance and needs a low-cost option, or they will stop using it — requires interprofessional coordination for access/cost, monitoring, and treatment plan.
7) Skin reactions — topical gels commonly cause local skin irritation.
8) Rotate injection sites to avoid irritation — standard counseling for injectable formulations.
9) Store at room temperature, away from children — recommended for most testosterone gels.
10) Testosterone gel — topical gels carry a risk of accidental transference to women or children.