Question

What effect did the Northern Blockade have on the South?

It had no effect on the South and they carried on as normal.
It did not affect the South because they could get their supplies from Mexico.
It caused the South to run out of much-needed supplies like medicine, shoes, and uniforms.
It caused issues with supplies right away but the South was able to quickly go back to normal.

Answer 1

It caused the South to run out of much-needed supplies like medicine, shoes, and uniforms.

Explanation: The Union blockade choked off Southern trade, preventing imports (and exports of cotton for funds), which produced shortages of medical supplies, clothing, boots, and other essentials despite efforts like blockade running and local substitution.