Question

1) For the treatment of bipolar I disorder, asenapine

can be used as a monotherapy.
is only approved as an adjunct treatment.
is only recommended for people who are 18 and older.
should never be used with lithium.
2) Asenapine has a high level of peripheral alpha-adrenergic receptor antagonism, which is most likely to be a concern for

tachycardia.
hypoglycemia.
vasoconstriction.
orthostatic hypotension.
3) Asenapine is approved for pediatric patients aged 10–17 years with

schizophrenia.
bipolar I disorder with manic or mixed episodes.
any psychosis due to a medical condition.
postural hypotension.
4) Asenapine should be stopped in a patient who develops an ANC level of

< 1,500/mm3.
> 1,500/mm3.
< 1,000/mm3.
>1,200/mm3.
5) Which of the following is an asenapine risk, particularly among older adults or those with cardiac concerns?

High incidence of hearing loss
QTc prolongation and arrhythmia risk
Increased risk of infection
Increased risk of hypertension
6) The recommended starting dose for asenapine for the treatment of schizophrenia is a _____ sublingual tablet twice a day.

10 mg
30 mg
5 mg
20 mg
7) With atypical antipsychotics such as asenapine, extrapyramidal symptoms (EPS)

may occur, but the risk is lower than with typical antipsychotics.
do not occur.
occur because drugs such as asenapine are strong CYP2D6 inhibitors.
occur when these drugs are discontinued.
8) Which of the following is NOT considered a likely risk factor for developing tardive dyskinesia in patients prescribed antipsychotics?

African-American ethnicity
Diabetes
High dose and long duration of use
Male sex
9) Asenapine is contraindicated if a patient has

severe renal impairment.
moderate hepatic impairment.
severe hepatic impairment.
moderate renal impairment
10) Which of the following is a possible benefit of asenapine compared to other antipsychotics for patients?

Low risk of dyslipidemias
High affinity to muscarinic receptors
High rates of extrapyramidal symptoms
Significant elevations of prolactin levels

Answer 1

1) can be used as a monotherapy.
2) orthostatic hypotension.
3) bipolar I disorder with manic or mixed episodes.
4) < 1,000/mm3.
5) QTc prolongation and arrhythmia risk.
6) 5 mg.
7) may occur, but the risk is lower than with typical antipsychotics.
8) Male sex.
9) severe hepatic impairment.
10) Low risk of dyslipidemias.