Question

1) Antipsychotic medications may cause ______________, a movement disorder whose symptoms include restlessness and needing to pace.

neuroleptic malignancy
serotonin syndrome
cardiac arrhythmia
akathisia
2) Aripiprazole is classified as a second-generation, atypical antipsychotic but it is also known as a _____________________ due to its unique mechanism of action.

anticonvulsant
third-generation antipsychotic
benzodiazepine
first-generation antipsychotic
3) The long-acting injectable (LAI) forms of aripiprazole exhibit ______________ kinetics that impact the time it takes for the drug to reach a steady state because of its slower absorption rate.

polypharmacy
placebo
flip-flop
peak–trough
4) Aripiprazole is classified as a dopamine partial agonist due to its ___________ activity at certain receptor targets, most notably D2 autoreceptors.

partial agonist
antagonist
blocking
full antagonist
5) Aripiprazole is FDA-approved as an adjunctive therapy to treat

major depressive disorder.
akathisia.
delusional disorder.
elderly patients with dementia-related psychosis.
6) True or False: Aristada Initio and Aristada should be injected into the same muscle when administered concurrently.

True
False
7) The long-acting injectable (LAI) aripiprazole may help promote adherence to antipsychotic medication treatment plans because

there are no adverse events with LAIs.
the dosing for LAIs is less frequent.
LAI formulations only use dehydroaripiprazole as the parent drug.
LAIs are administered daily.
8) Aripiprazole has FDA approval for treating irritability in children who have

bipolar 1.
schizophrenia.
autism spectrum disorder.
akathisia.
9) Patients taking aripiprazole should be counseled that

there is no risk of metabolic side effects or weight gain.
only children are at risk of extrapyramidal symptoms.
oculogyric crisis (OGC) is relatively common and self-resolving.
an association between the use of aripiprazole and compulsive behaviors, including gambling, binge eating, shopping, or engaging in sex has been reported.
10) Women of childbearing age should be informed of the following about taking aripiprazole during pregnancy:

children exposed to aripiprazole during pregnancy are at a higher risk of adverse effects than those exposed to other antipsychotics.
antipsychotics in the third trimester pose no risk of adverse effects.
animal studies suggest risks of adverse effects on the fetus, but benefits may outweigh risks in certain patients.
aripiprazole is contraindicated in pregnant women.

Answer 1

1) akathisia

2) third-generation antipsychotic

3) flip-flop

4) partial agonist

5) major depressive disorder

6) False

7) the dosing for LAIs is less frequent

8) autism spectrum disorder

9) an association between the use of aripiprazole and compulsive behaviors, including gambling, binge eating, shopping, or engaging in sex has been reported

10) animal studies suggest risks of adverse effects on the fetus, but benefits may outweigh risks in certain patients