Asked by Brooklyn
3. Below is a simplified LDL transport diagram with possible mutations that could occur along the pathway to include LDLR, PCSK9, and ApoB.
Click on the part of the diagram that if mutated, would prevent LDL particles from binding properly.
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Click on ApoB.
Reason: ApoB is the apolipoprotein on the LDL particle that directly binds the LDL receptor. Mutations in ApoB (e.g., familial defective ApoB‑100) disrupt that interaction and prevent proper LDL binding. (PCSK9 alters receptor levels; LDLR mutations can also impair binding, but ApoB is the ligand whose mutation specifically prevents LDL particles from binding.)
Reason: ApoB is the apolipoprotein on the LDL particle that directly binds the LDL receptor. Mutations in ApoB (e.g., familial defective ApoB‑100) disrupt that interaction and prevent proper LDL binding. (PCSK9 alters receptor levels; LDLR mutations can also impair binding, but ApoB is the ligand whose mutation specifically prevents LDL particles from binding.)
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