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Use the text “Rethinking a Holiday” to answer the question.

Rethinking a Holiday

Which piece of evidence best supports the idea that Christopher Columbus’s voyages spread deadly diseases?

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Responses

Within 50 years of contact with the Spanish, the native Tainos, who welcomed Columbus in 1492, no longer existed as a distinct group.
Within 50 years of contact with the Spanish, the native Tainos, who welcomed Columbus in 1492, no longer existed as a distinct group.

Contact between Europeans and native people led to deadly conflicts.
Contact between Europeans and native people led to deadly conflicts.

Just prior to Spanish arrival in 1492, it is believed that an estimated 50–100 million indigenous people lived in the Americas.
Just prior to Spanish arrival in 1492, it is believed that an estimated 50–100 million indigenous people lived in the Americas.

Millions of indigenous people died of smallpox, measles, cholera, and other contagious illnesses.
Millions of indigenous people died of smallpox, measles, cholera, and other contagious illnesses.
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Answered by GPT-5 mini AI
Millions of indigenous people died of smallpox, measles, cholera, and other contagious illnesses.

This statement directly links European contact to the spread of deadly diseases and the resulting deaths.