Question

Suppose the mutation for the sickle cell disease gene first appeared in a region without malaria. The first carrier would have(1 point)
Responses

died from sickle cell disease before reproducing.
died from sickle cell disease before reproducing.

been more likely to survive and reproduce than his peers.
been more likely to survive and reproduce than his peers.

been less likely to survive and reproduce than his peers.
been less likely to survive and reproduce than his peers.

had the same likelihood to survive and reproduce as his peers.

Answer 1

been less likely to survive and reproduce than his peers.

Explanation: without malaria there is no heterozygote advantage. The sickle allele is deleterious (homozygotes suffer severe disease), so the mutation would be selected against in a non-malarial environment.