Question

Which line from The Strange Case of Dr. Jekyll and Mr. Hyde best characterizes Dr. Jekyll as ill?

He did not rise to meet his visitor, but held out a cold hand and bade him welcome in a changed voice.
The doctor shuddered. “They were crying it in the square,” he said. “I heard them in my dining-room.”
“Utterson, I swear to God,” cried the doctor, “I swear to God I will never set eyes on him again . . .”
He was busy, he was much in the open air, he did good; his face seemed to open and brighten . . .

Answer 1

"He did not rise to meet his visitor, but held out a cold hand and bade him welcome in a changed voice."

That description shows physical weakness and a “changed” (ill-sounding) voice — direct signs of sickness. The others show fear, resolve, or recovery rather than clear physical illness.