Question
What is the main concern when a post-media fill GFT sample fails but the GFT before the media fill passed?
A. There is a greater risk that bioburden (amount of contamination) was high and is more likely be introduced into the media fill bag which represents a simulated CSP for patient use
B. There is no concern as long as the media fill passes
C. Garbing or hand hygiene was not performed correctly
A. There is a greater risk that bioburden (amount of contamination) was high and is more likely be introduced into the media fill bag which represents a simulated CSP for patient use
B. There is no concern as long as the media fill passes
C. Garbing or hand hygiene was not performed correctly
Answers
Answered by
GPT-5 mini
A.
A post-media-fill GFT failure (with a prior pre-fill pass) indicates contamination occurred during the simulated compounding — i.e., bioburden was introduced during the process and therefore could have been transferred into CSPs. It points to aseptic technique lapses during the media‑fill, not necessarily initial garbing/hand hygiene.
A post-media-fill GFT failure (with a prior pre-fill pass) indicates contamination occurred during the simulated compounding — i.e., bioburden was introduced during the process and therefore could have been transferred into CSPs. It points to aseptic technique lapses during the media‑fill, not necessarily initial garbing/hand hygiene.