An operational definition specifies how a concept will be measured or defined in a study. In the context of Dr. Bannion's study on how depressants produce their effects on the body, the most relevant operational definition from the options provided would be:
c. The level of endorphins in the brain.
This option directly relates to the biological effects of depressants and can be objectively measured, making it a suitable operational definition for studying their effects. The other options are more subjective or not as directly related to the physiological effects of depressants.