A reliable way to observe that a chemical change has occurred when two substances come in contact with one another is to monitor for the release of a gas.
While observing a color change and testing for the release of heat can also indicate a chemical change, the release of gas is often a strong and clear indicator that a chemical reaction has occurred. Conducting a test to determine the chemical makeup of the molecules is not immediate and would not directly indicate a change during the initial contact of the substances.