All of the countries listed—Spain, Germany, England, and the Netherlands—established mission systems as part of their colonial strategies at various points in history. However, if you are looking for a specific answer based on the prominence of mission systems in their colonial efforts, the most notable example would be Option A: Spain. Spain implemented extensive missionary programs, particularly in the Americas and the Philippines, to convert indigenous populations to Christianity as part of their colonial administration.
That said, England (particularly in North America and parts of Africa), the Netherlands (in their Indonesian territories), and Germany (in Africa) also had missionary activities, but they were not as central to their colonial strategies as in the case of Spain.