The main conflicts faced in Florida primarily resulted from territorial disputes with Spain. Throughout the 18th and early 19th centuries, Florida was a point of contention between Spain and the United States, particularly as the U.S. expanded its territory. The desire to acquire Florida led to various tensions and conflicts, including the First Seminole War and negotiations over treaties.
While issues like limited land and resources for settlement, pirate attacks, and warfare between European powers did have an impact on the region, the most significant and direct conflicts were centered around the disputes with Spain over control of Florida.