The answer that best describes how the cotton gin changed cotton farming is:
The cotton gin made growing cotton very profitable and increased the demand for slave labor.
The invention of the cotton gin in the late 18th century significantly increased the efficiency of cotton processing, making it much easier to separate cotton fibers from seeds. This resulted in a boom in cotton production, making it a highly profitable crop and consequently leading to an increase in the demand for slave labor to cultivate and harvest the cotton on plantations.