Mycobacterium tuberculosis resists intracellular killing primarily by B. inhibiting phagosome-lysosome fusion.
This ability allows it to survive and replicate inside the macrophages, which are normally equipped to kill pathogens through the fusion of phagosomes with lysosomes, where destructive enzymes are present. The other options listed do not accurately describe the mechanism by which M. tuberculosis evades intracellular killing.