Primary immunodeficiency disorders (PIDDs) are usually due to intrinsic defects in the immune system. These disorders are typically caused by genetic mutations that lead to malfunctions in various components of the immune response, including B cells, T cells, phagocytes, and the complement system. These defects can affect the development, function, or regulation of immune cells, resulting in an increased susceptibility to infections, autoimmune diseases, or malignancies. PIDDs can be inherited in various patterns, including X-linked, autosomal dominant, or autosomal recessive. Each specific disorder may impact different aspects of immune function, leading to a diverse range of clinical presentations.
Primary immunodeficiency disorders are usually due to...
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