Which of the following European diseases was responsible for the greatest number of American Indian deaths in the late 15th and early 16th centuries?

Question

smallpox

bubonic plague

measles

influenza

Answer 1

The disease responsible for the greatest number of American Indian deaths in the late 15th and early 16th centuries was smallpox. Smallpox had a devastating impact on Native American populations, as they had no prior exposure or immunity to the disease, leading to high mortality rates.