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An amino acid analysis of the DNA polymerase gene in humans determines that the sequence of the active site is: Val-Gly-Thr-Ser-Cys-Pro. Based on this information, which species below would be considered the most evolutionarily related to humans?(1 point)

Responses

Species 4: Leu-Val-Met-Thr-Tyr-Pro
Species 4: Leu-Val-Met-Thr-Tyr-Pro

Species 1: Gly-Leu-Ser-Thr-Cys-Pro
Species 1: Gly-Leu-Ser-Thr-Cys-Pro

Species 2: Val-Gly-Phe-Tyr-Asn-Pro
Species 2: Val-Gly-Phe-Tyr-Asn-Pro

Species 3: Val-Gly-Thr-Ser-Tyr-Pro

1 answer

To determine which species is the most evolutionarily related to humans based on the active site sequence of the DNA polymerase gene, we have to compare the sequences provided with the human sequence: Val-Gly-Thr-Ser-Cys-Pro.

Let's analyze the sequences one by one:

  • Species 1: Gly-Leu-Ser-Thr-Cys-Pro

    • Comparison to human sequence:
      • Gly (vs Val) - different
      • Leu (vs Gly) - different
      • Ser (vs Thr) - different
      • Thr (vs Ser) - different
      • Cys (matches) - same
      • Pro (matches) - same
    • Total matches: 2/6

  • Species 2: Val-Gly-Phe-Tyr-Asn-Pro

    • Comparison to human sequence:
      • Val (matches) - same
      • Gly (matches) - same
      • Phe (vs Thr) - different
      • Tyr (vs Ser) - different
      • Asn (vs Cys) - different
      • Pro (matches) - same
    • Total matches: 4/6

  • Species 3: Val-Gly-Thr-Ser-Tyr-Pro

    • Comparison to human sequence:
      • Val (matches) - same
      • Gly (matches) - same
      • Thr (matches) - same
      • Ser (matches) - same
      • Tyr (vs Cys) - different
      • Pro (matches) - same
    • Total matches: 5/6

  • Species 4: Leu-Val-Met-Thr-Tyr-Pro

    • Comparison to human sequence:
      • Leu (vs Val) - different
      • Val (matches) - same
      • Met (vs Thr) - different
      • Thr (matches) - same
      • Tyr (vs Cys) - different
      • Pro (matches) - same
    • Total matches: 4/6

Based on this comparison, Species 3: Val-Gly-Thr-Ser-Tyr-Pro has the highest number of matches (5 out of 6) with the human sequence. Therefore, Species 3 would be considered the most evolutionarily related to humans.