how were the differences important to the international state of affairs in 1450?

Answer 1

What differences?

Answer 2

I wonder if it is important what differences you are thinking on? http://www.historycentral.com/dates/1400ad.html

Answer 3

the differences between asia, eurasia,and europe and the impact it had on the international state of affairs in 1450

Answer 4

Check your textbook or some of these sites.

http://www.google.com/search?source=ig&hl=en&rlz=1G1GGLQ_ENUS308&q=world+1450&aq=f&aqi=&aql=&oq=&gs_rfai=CgyWKVoWfTK3tDJSmoATTv5ydAwAAAKoEBU_Q8weU

Answer 5

"...and the impact it had ..."

The impact WHAT had? No one can guess what "it" is.