The sequence given is:
1, 6, 36, 216,
Let's examine the relationship between the terms:
- 1 = 1
- 6 = 1 × 6
- 36 = 6 × 6
- 216 = 36 × 6
It appears that each term is obtained by multiplying the previous term by 6.
To find the next term after 216, we multiply 216 by 6:
216 × 6 = 1296
So, the missing number in the sequence is 1296.