The correct response regarding how the structure of atoms in a substance determines the substance’s conductivity is:
"If an atom’s outer shell of electrons is loosely bound to the nucleus, the substance is a good conductor."
In conductive materials, such as metals, the outer electrons are not tightly bound to their respective nuclei and can move freely, allowing for efficient electrical conduction. In contrast, in insulators, the outer electrons are tightly bound and do not move easily, resulting in low conductivity.