In "The Diary of a Young Girl" by Anne Frank, the setting transitions between different contexts throughout the narrative. Based on the options you've provided, the most accurate description of the difference in setting between Scene 1 and Scene 2 is:
Scene 1 takes place in the Secret Annex, and Scene 2 happens at the Franks' original apartment.
In the diary, the Secret Annex is the hidden space where Anne and her family, along with the Van Daans and later Fritz Pfeffer, live in hiding during the Nazi occupation, while the Franks' original apartment is where they lived before going into hiding. This distinction highlights the drastic change in their circumstances due to the war.