The quotation that best highlights the idea of a sense of familiarity in Mariposa is:
B. "People simply speak of the 'lake' and the 'river' and the 'main street,' much in the same way as they always call the Continental Hotel, 'Pete Robinson's' and the Pharmaceutical Hall, 'Eliot's Pharmacy.'" (Paragraph 3)
This quote emphasizes how the local inhabitants have an intimate, well-known connection to their surroundings through the nicknames and common references they use, conveying a strong sense of familiarity within the community.