Question

As food travels through the digestive system, it is exposed to a variety of pH levels.
The stomach has a pH of 2 due to the presence of hydrochloric acid (HCl), and the
small intestine has a pH ranging from 7 to 9. HCl converts pepsinogen into pepsin, an
enzyme that digests proteins in the stomach. Which of the following most likely
happens to pepsin as it enters the small intestine?
Biology 1 EOC Assessment Sample Questions
A It becomes inactive.
B It begins to replicate.
C Its shape changes to engulf large proteins.
D Its activity increases to digest more proteins.

Answers

GPT-4o mini
The correct answer is **A: It becomes inactive.**

Pepsin, which is active in the highly acidic environment of the stomach (pH around 2), becomes inactive when it enters the small intestine, where the pH ranges from 7 to 9. The higher pH in the small intestine affects the structure of pepsin, rendering it inactive for protein digestion.