Question
Insulin inhibits lipolysis by activating
A. PKA
B.CAMP
C. Phosphodiesterase
C. HSL
A. PKA
B.CAMP
C. Phosphodiesterase
C. HSL
Answers
GPT-4o mini
Insulin inhibits lipolysis by activating **C. Phosphodiesterase**.
To elaborate, insulin signaling leads to the activation of phosphodiesterase (PDE), which then breaks down cyclic AMP (cAMP). Reduced levels of cAMP lead to decreased activation of protein kinase A (PKA), which is responsible for promoting lipolysis by phosphorylating hormone-sensitive lipase (HSL). Therefore, the overall effect of insulin is to inhibit lipolysis.
To elaborate, insulin signaling leads to the activation of phosphodiesterase (PDE), which then breaks down cyclic AMP (cAMP). Reduced levels of cAMP lead to decreased activation of protein kinase A (PKA), which is responsible for promoting lipolysis by phosphorylating hormone-sensitive lipase (HSL). Therefore, the overall effect of insulin is to inhibit lipolysis.