To revise the simplified model of protein synthesis for a more accurate depiction, option A is the most appropriate choice:
A) Between processes 1 and 2, the mRNA must leave the nucleus.
This reflects the critical step in eukaryotic cells where the mRNA, which is transcribed from DNA in the nucleus, must exit the nucleus and enter the cytoplasm before it can be translated into a protein by ribosomes. The other options either introduce inaccuracies or do not accurately reflect key aspects of the protein synthesis process.
- Option B refers to DNA replication, which is not directly relevant to the process of protein synthesis itself.
- Option C incorrectly suggests that proteins return to the nucleus, which they typically do not, as their primary function is in the cytoplasm.
- Option D suggests that ribosomes can remove mutated nucleotides from mRNA, but ribosomes do not have this capability; mRNA is typically transcribed with the mutations, and such errors are usually addressed by mechanisms such as RNA editing or by the cell's quality control systems post-transcription.