The most accurate response regarding the impact of Andrew Jackson's presidency on American Indians of Tennessee is:
It caused thousands of American Indians in the east to lose their lands due to the Indian Removal Act.
During Andrew Jackson's presidency, particularly with the implementation of the Indian Removal Act of 1830, thousands of Native Americans were forcibly removed from their ancestral lands in the southeastern United States, including Tennessee. This act led to the infamous Trail of Tears, where many Native Americans suffered greatly as they were relocated to designated Indian Territory in the west.