The most accurate response to how "The Hound of the Baskervilles" might have influenced literature in the 20th and 21st centuries is:
Modern mysteries follow similar story patterns with a detective being presented with a crime or problem that must be solved.
This option highlights the legacy of detective fiction established by Arthur Conan Doyle, particularly the structure of introducing a central mystery that must be unraveled by the detective, a pattern that continues to be a hallmark of the genre today.