Among the scenarios you provided, the one that will always lead to natural selection is:
- A mutation causes a specific advantage within the population.
This scenario directly contributes to natural selection because if a mutation provides a specific advantage, individuals with that mutation are more likely to survive and reproduce, passing the advantageous traits to the next generation.
The other scenarios may affect a population but do not guarantee that natural selection will occur:
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A mutation that causes a gene to become inactivated may be neutral or detrimental, depending on the context, and might not lead to a selective advantage.
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A mutation causing an inactivated gene to be reactivated could also vary in its effects. It might be advantageous, neutral, or detrimental.
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A mutation causing a specific variation within the population doesn’t necessarily lead to natural selection unless that variation provides a differential advantage or disadvantage in reproductive success.
Thus, the first option is the most directly associated with natural selection.