CIPA (Congenital Insensitivity to Pain with Anhidrosis) is a condition that affects the ability to feel pain and temperature, which specifically involves the dysfunction of thermoreceptors (sensitive to temperature) and nociceptors (sensitive to pain). However, since nociceptors aren't listed as an option, the correct response that aligns with the inability to sense temperature is thermoreceptors.
Given the provided response options, the best fitting would be "thermoreceptors and mechanoreceptors" since mechanoreceptors respond to mechanical pressures and distortions. However, mechanoreception is not directly related to pain or temperature sensation.
Thus, the most appropriate option for what is affected in terms of inability to feel pain and temperature (counting thermoreceptors which are essential for temperature sensation) is:
- thermoreceptors and mechanoreceptors.