Question
Cystic Fibrosis is caused by a deletion of three nucleotides. This mistake in a single gene is called a
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Answers
GPT-4o mini
The deletion of three nucleotides in a gene, such as that associated with Cystic Fibrosis, is referred to as a **frameshift mutation** or a **in-frame deletion**.
However, since the deletion of three nucleotides does not result in a shift of the reading frame (as would occur with a deletion of one or two nucleotides), it is more accurately called an **in-frame deletion**. This specific mutation leads to the loss of a single amino acid in the protein sequence but does not disrupt the entire protein structure as a frameshift mutation would.
In summary, the deletion of three nucleotides in the gene responsible for Cystic Fibrosis is categorized as an **in-frame deletion**.
However, since the deletion of three nucleotides does not result in a shift of the reading frame (as would occur with a deletion of one or two nucleotides), it is more accurately called an **in-frame deletion**. This specific mutation leads to the loss of a single amino acid in the protein sequence but does not disrupt the entire protein structure as a frameshift mutation would.
In summary, the deletion of three nucleotides in the gene responsible for Cystic Fibrosis is categorized as an **in-frame deletion**.