Based on the trends of the periodic table, the most likely element to combine with magnesium (Mg) from the options provided is:
C. oxygen (O)
Magnesium is a highly reactive metal and oxygen is a reactive nonmetal, and when they combine, they typically form magnesium oxide (MgO). Helium (He) is a noble gas and does not react, gold (Au) is a metal that does not readily react with magnesium, and sodium (Na), while a reactive metal, would not typically combine directly with magnesium but could form a different compound. Therefore, the best answer is oxygen (O).