Here are the responses matched to the appropriate descriptions:
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Deadliest single-day battle of the war; showed Union could stand against the Confederacy - Battle of Antietam
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Location where Confederacy surrendered to the Union; ended the Civil War - Appomattox Court House
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Union captured the Mississippi River; divided the Confederacy in half - Battle of Vicksburg
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Turning point of the Civil War; ended any further advancement of the Confederacy - Battle of Gettysburg