The statement that best describes how the Comstock Lode affected the western part of the United States is:
2. Thousands of prospectors traveled west in search of gold and silver.
The discovery of the Comstock Lode in Nevada in 1859 led to a significant influx of miners and prospectors to the West, contributing to the westward expansion and the rapid development of towns and cities in the region. This migration was spurred by the hope of striking it rich, and it played a crucial role in shaping the economic and social landscape of the American West.