The significance of the Spanish Inquisition is best captured by the following point:
It resulted in the persecution of non-Christians, particularly Jews and Muslims, in Spain.
The Spanish Inquisition, established in 1478, was primarily aimed at maintaining Catholic orthodoxy in the newly unified Spain. It led to the persecution, forced conversions, and expulsion of thousands of Jews and Muslims, profoundly affecting the religious and cultural landscape of Spain during that era. While the Inquisition did have some indirect influences on trade and exploration, its most direct and significant impact was the enforcement of religious conformity and the resulting persecution of non-Christians.