Question

Research: Congenital Lactose Intolerance
Write your response in one well-structured paragraph (5–7 sentences).

Answer 1

Congenital lactose intolerance, also known as congenital alactasia, is a rare genetic disorder characterized by the complete absence of lactase, the enzyme responsible for breaking down lactose, the sugar found in milk and dairy products. This condition is typically identified in infants shortly after birth when they experience severe gastrointestinal symptoms, such as diarrhea, abdominal pain, and bloating, after consuming lactose-containing foods. The disorder is inherited in an autosomal recessive manner, often linked to mutations in the LCT gene, which encodes the lactase enzyme. Unlike transient lactose intolerance, which can occur due to temporary conditions affecting the intestine, congenital lactose intolerance is a lifelong condition requiring strict dietary management from an early age. Affected individuals must adopt a lactose-free diet to prevent symptoms and maintain their health, which necessitates careful monitoring of nutrient intake, particularly calcium and vitamin D. Early diagnosis and intervention are crucial for preventing complications and ensuring proper growth and development in affected infants. Overall, understanding congenital lactose intolerance is essential for providing appropriate care and dietary education to families dealing with this condition.