The Team Fortress 2 Sniper is a highly skilled marksman with exceptional accuracy and reflexes, as well as a stealthy and cunning personality. Based on these traits, he could likely defeat characters who lack similar levels of skill or combat experience.
For example, the Sniper could potentially take down characters like:
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Shaggy from Scooby-Doo: While Shaggy has become a meme for his supposed ultra-competent abilities in fighting, traditionally he's portrayed as cowardly and not a skilled fighter, making him an easy target for the Sniper's long-range skills.
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Courage from Courage the Cowardly Dog: Courage is known for his cowardice and often finds himself in comedic situations, making him a poor match against a skilled assassin like the Sniper.
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SpongeBob SquarePants: Although SpongeBob has some quirky resilience and supernatural abilities, in a serious confrontation, the Sniper's precision and tactics would likely outmatch SpongeBob's often goofy and non-combative nature.
Keep in mind that matchups like these often depend heavily on context and the interpretation of the characters involved!