When preparing a speech, it is always a good idea to pretend you are an audience member and ask yourself how your message will resonate with them. The best response to consider is related to the audience's perspective and their needs.
So, while none of the options provided are particularly ideal, the closest to an audience-centric approach would be to consider how they might personally benefit from your message or content. Thus, if we had to select from the options given, the response "How can this message personally benefit me?" would be the most relevant, albeit in terms of understanding the audience's perspective rather than a self-serving viewpoint.
However, it's critical to frame this in a way that focuses on the audience rather than yourself: "How can this message benefit the audience?" would be the best approach for speech preparation.