The condition CIPA (Congenital Insensitivity to Pain with Anhidrosis) affects an individual's ability to perceive pain and temperature. This condition primarily involves the impairment of thermoreceptors, which are responsible for detecting temperature changes, and nociceptors, which are responsible for detecting pain.
Since nociceptors are not listed among the options, the most relevant choice based on the options provided is:
thermoreceptors and mechanoreceptors.
This option includes thermoreceptors, which are directly affected by the inability to feel temperature. However, mechanoreceptors, while involved in sensing touch and pressure, are not primarily affected by CIPA concerning pain and temperature perception.
So, the best response from the available options is: thermoreceptors and mechanoreceptors.