Which of the following was the greatest short-term effect of Spanish colonization on American Indians?

it sharply decreased their population, it opened them to European ideas, it gave them new crops to grow, it led to their disappearance from the Americas

1 answer

The greatest short-term effect of Spanish colonization on American Indians was that it sharply decreased their population. This decline was primarily due to factors such as disease brought by Europeans, which decimated Indigenous populations, as well as violence and harsh treatment associated with colonization. While there were other effects, such as exposure to European ideas and new crops, the immediate and significant impact on population was the most pronounced.