The main difference between small, controlled lab experiments and ecosystem-scale experiments is primarily the applicability of the results.
In controlled lab experiments, conditions can be tightly regulated, allowing for precise manipulation of variables, but the results may not always translate well to real-world ecosystems. Ecosystem-scale experiments, on the other hand, involve a broader range of abiotic and biotic factors and can provide insights that are more applicable to natural environments, despite being more complex and less controllable.
While the number of variables, abiotic factors, and species of interest can also differ, the key distinction lies in how universally the findings from each type of experiment can be applied to understand broader ecological phenomena.