If the sun disappeared from the universe, it would affect all spheres, including the atmosphere, biosphere, lithosphere, and hydrosphere. The atmosphere would be affected due to the lack of solar energy, which is crucial for maintaining temperature and weather patterns. The biosphere would be heavily impacted as all life on Earth depends on sunlight for photosynthesis and warmth. The lithosphere and hydrosphere would also be indirectly affected as the absence of the sun would alter weather patterns, ocean currents, and geological processes over time.
So, the most accurate response would be all spheres.