The statement that best analyzes a key difference between European expansion in the Western and Eastern Hemispheres is:
In the Eastern Hemisphere, Europeans were able to set up trade relationships with different peoples, but in the Western Hemisphere, Europeans focused on conquering different peoples.
This statement accurately reflects the differing approaches Europeans took during their expansion; in the Eastern Hemisphere, trade and economic relationships were often prioritized, whereas in the Western Hemisphere, conquest and colonization were more prevalent.