To simplify \((5x^4)^2\), you apply the power to both the coefficient and the variable:
- Square the coefficient: \(5^2 = 25\).
- Square the variable \(x^4\): \((x^4)^2 = x^{4 \cdot 2} = x^8\).
Putting it all together:
\[ (5x^4)^2 = 25x^8 \]
So, the correct response is 25x^8.