Here are the answers to your questions based on the information provided:
Question 1: For a mutation to have an effect on the species as a whole, it must:
- Be inheritable and be able to be passed on to offspring.
Question 2: What is best to determine if species are closely related?
- They have similar genetic make up.
These answers emphasize the importance of genetic inheritance for evolutionary changes and the significance of genetic similarity in determining relationships between species.